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O4–04–01: Dementia epidemiology in Korea: Comparison of the results from the Nationwide Survey on the Dementia Epidemiology (NaSDEK) 2008 and the NaSDEK 2012
Author(s) -
Han Jiwon,
So Yoonseop,
Kim Tae Hui,
Lee Dong Young,
Ryu SeungHo,
Kim Seong Yoon,
Kim Shin Gyeom,
Kim ShinKyum,
Yoon Jong Chul,
Jhoo Jin Hyeong,
Kim JeongLan,
Lee Seok Bum,
Lee Jung Jae,
Kwak Kyung Phil,
Moon Seok Woo,
Kim BongJo,
Bae Jae Nam,
Woo Jong Inn,
Jeong Hyeon,
Park Joon Hyuk,
Kim Ki Woong
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.04.352
Subject(s) - dementia , epidemiology , medicine , population , gerontology , disease , psychiatry , environmental health
3M/4F), were assessed at UCL. Based on Clinical Dementia Rating (CDR), 12 carriers were asymptomatic (aMut+; CDR 1⁄4 0; mean age 1⁄4 35; 4M/8F) and eight symptomatic (sMut+; CDR 1⁄4 0.5-1; mean age 1⁄4 47; 5M/3F). Frontal, striatal (caudate and pallidum) and thalamic ’nodes’ of the loops of interest were automatically parcellated from structural MRI. Thalamofrontal tractography was performed for the NC, both via striatal ’waypoints’ and directly. The tracts were normalized, registered to standard space, averaged and thresholded. Tract average fractional anisotropy (FA) and mean diffusivity (MD) were then computed from native images using these template tracts. Effective connectivity between nodes was sDCM-estimated from the fMRI data (Figure.). Linear regression was used to compare metrics between groups (NC, aMut+, sMut+), adjusted for age and gender. Results: Both tract FA and MD revealed group differences: significant sMut+ > NC differences were found for all three loops (aCC, dlPFC and latOFC) bilaterally. Compared to aMut+, sMut+ had higher MD in right dlPFC-thalamus tract and lower FA and higher MD in right latOFC-thalamus tract. The aMut+ had lower FA than NC in left thalamus-latOFC tract. sDCM suggested left-hemisphere aCC connectivity abnormalities for sMut+ relative to both NC and aMut+. No sDCM differences were observed between aMut+ and NC. The Table shows these results and group-average FA, MD and connectivity values. Conclusions: Fronto-striato-thalamic tract structure is altered in FAD. Abnormal effective connectivity was also suggested by sDCM, but requires confirmation in a larger cohort.