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F3–02–03: Imaging of α4β2 nicotinic acetylcholine receptors in neurodegenerative disorders using 2‐[18F]F‐A85380 and [18F]Flubatine
Author(s) -
Sabri Osama
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.04.228
Subject(s) - posterior cingulate , precuneus , neuroscience , dementia with lewy bodies , dementia , nicotinic agonist , hippocampus , thalamus , medicine , psychology , cortex (anatomy) , disease , receptor , cognition
any one of six ROIs or by exceeding the SUVR threshold in the global cortical region. Results: Twenty-one subjects were found to be PiB+, with age highly related to PiB+ status (p < 0.0001). For individuals age of 40 and older (N1⁄425), 72% were PiB+. Significant age-dependent increases in amyloid deposition were seen in all regions, with greatest increases seen in the anterior ventral striatum (R 2 1⁄40.64). PiB+ subjects evidenced significantly lower mean scores on several neuropsychological measures, including executive/working memory, delayed recall, and attention/processing speed. These differences are hypothesized to become more pronounced at follow-up time points. Conclusions: This study offers an important opportunity to study the preclinical manifestations of AD. Follow-up assessments at 30-month intervals may not only provide information that could affect early detection, prevention, and treatment of AD for individuals with DS, but also may offer information that will prove extremely useful for the general population.