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O2–02–04: Hypometabolism in PiB‐positive, population‐based, cognitively normal subjects with and without APOE‐ε4
Author(s) -
Weigand Stephen,
Lowe Val,
Senjem Matthew,
Vemuri Prashanthi,
Kantarci Kejal,
Knopman David,
Boeve Bradley,
Petersen Ronald,
Jack Clifford
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.04.144
Subject(s) - posterior cingulate , pittsburgh compound b , logistic regression , apolipoprotein e , medicine , population , psychology , cardiology , cognitive impairment , neuroscience , cortex (anatomy) , disease , environmental health
MCIs additionally showed clinical decline accelerated by declines in longitudinal FDG (interaction p<0.015). Conclusions: These data indicate that in CN individuals, FDG declines are largely independent of beta-amyloid and carrier status, and that baseline levels of FDG metabolism in AD-like brain regions predict degree of clinical decline regardless of beta-amyloid or APOE-ε4 status. Variance in clinical decline exceeds that accounted for by beta-amyloid or APOE status, and is related to baseline FDG, suggesting that nonbeta-amyloid, non-APOE factors are detectable in AD-like regions and are associated with decline.