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IC‐O3–01: The Centiloid Scale: Standardization of amyloid imaging measures
Author(s) -
Rowe Christopher,
Klunk William,
Koeppe Robert,
Jagust William,
Pontecorvo Michael,
Devous Michael,
Howlett Marybeth,
Skovronsky Daniel,
Johnson Keith,
Price Julie,
Mathis Chet,
Mintun Mark
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.04.026
Subject(s) - outlier , standardization , computer science , artificial intelligence , metric (unit) , standard deviation , gold standard (test) , pattern recognition (psychology) , mathematics , nuclear medicine , statistics , medicine , operations management , economics , operating system
and potentially in healthy controls via affordable and widely available multimodal-MRI. Our previous publications indicate that hippocampal volume is by itself a poor predictor of amyloid status, although a signature pattern of regional brain atrophy including hippocampal atrophy does associate with Ab+ and this signal is stronger if ApoE-ε4-status is included in the model. An even stronger signal is obtained with CBF-measures from ASL-MRI; and the combination of atrophy and CBF is even better yet.