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Diagnosing Alzheimer's disease: A systematic review of economic evaluations
Author(s) -
Handels Ron L.H.,
Wolfs Claire A.G.,
Aalten Pauline,
Joore Manuela A.,
Verhey Frans R.J.,
Severens Johan L.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.02.005
Subject(s) - economic evaluation , systematic review , psychological intervention , management science , disease , health technology , medline , psychology , medicine , health care , psychiatry , pathology , political science , economics , law
Background The objective of this study is to systematically review the literature on economic evaluations of interventions for the early diagnosis of Alzheimer's disease (AD) and related disorders and to describe their general and methodological characteristics. We focused on the diagnostic aspects of the decision models to assess the applicability of existing decision models for the evaluation of the recently revised diagnostic research criteria for AD. Methods PubMed and the National Institute for Health Research Economic Evaluation database were searched for English‐language publications related to economic evaluations on diagnostic technologies. Trial‐based economic evaluations were assessed using the Consensus on Health Economic Criteria list. Modeling studies were assessed using the framework for quality assessment of decision‐analytic models. Results The search retrieved 2109 items, from which eight decision‐analytic modeling studies and one trial‐based economic evaluation met all eligibility criteria. Conclusions Diversity among the study objective and characteristics was considerable and, despite considerable methodological quality, several flaws were indicated. Recommendations were focused on diagnostic aspects and the applicability of existing models for the evaluation of recently revised diagnostic research criteria for AD.