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Subjective cognitive decline: Self and informant comparisons
Author(s) -
Caselli Richard J.,
Chen Kewei,
Locke Dona E.C.,
Lee Wendy,
Roontiva Auttawut,
Bandy Dan,
Fleisher Adam S.,
Reiman Eric M.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.01.003
Subject(s) - cognitive decline , psychology , cognition , distress , clinical psychology , cohort , cognitive impairment , gerontology , medicine , dementia , disease , psychiatry
Background It is unclear whether self‐ or informant‐based subjective cognition better distinguishes emotional factors from early‐stage Alzheimer's disease (AD). Methods Healthy members (n = 447) of the Arizona apolipoprotein E ( APOE ) cohort and their informants completed the self and informant paired Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS). Results Decline on the MANS was endorsed by 30.6% of members and 26.2% of informants. Self‐ and informant‐based decliners had higher scores of psychological distress and slightly lower cognitive scores than nondecliners. Over the next 6.7 years, 20 developed mild cognitive impairment (MCI). Converters were older at entry than nonconverters (63.8 [7.0] vs 58.8 [7.3] years, P = .003), 85% were APOE ε4 carriers ( P < .0001), and they self‐endorsed decline earlier than informants (58.9 [39.2] vs 28.0 [40.4] months before MCI; P = .002). Conclusions Self‐ and informant‐based subjective decline correlated with greater psychological distress and slightly lower cognitive performance. Those with incident MCI generally self‐endorsed decline earlier than informants.