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Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
Author(s) -
Rembach Alan,
Faux Noel G.,
Watt Andrew D.,
Pertile Kelly K.,
Rumble Rebecca L.,
Trounson Brett O.,
Fowler Christopher J.,
Roberts Blaine R.,
Perez Keyla A.,
Li QiaoXin,
Laws Simon M.,
Taddei Kevin,
RaineySmith Stephanie,
Robertson Joanne S.,
Vandijck Manu,
Vanderstichele Hugo,
Barnham Kevin J.,
Ellis Kathryn A.,
Szoeke Cassandra,
Macaulay Lance,
Rowe Christopher C.,
Villemagne Victor L.,
Ames David,
Martins Ralph N.,
Bush Ashley I.,
Masters Colin L.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.12.006
Subject(s) - biomarker , amyloid (mycology) , neuroimaging , neuropsychology , disease , medicine , amyloid beta , alzheimer's disease , oncology , dementia , alzheimer's disease neuroimaging initiative , psychology , pathology , cognition , psychiatry , biology , biochemistry
Background A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer's disease (AD). Methods Plasma amyloid beta (Aβ) 1–40 , Aβ 1–42 , Aβ n–40 , and Aβ n–42 peptides were measured at baseline and after 18 months in 771 participants from the Australian Imaging Biomarkers and Lifestyle (AIBL) study of aging. Aβ peptide levels were compared with clinical pathology, neuroimaging and neuropsychological measurements. Results Although inflammatory and renal function covariates influenced plasma Aβ levels significantly, a decrease in Aβ 1–42 /Aβ 1–40 was observed in patients with AD, and was also inversely correlated with neocortical amyloid burden. During the 18 months, plasma Aβ 1–42 decreased in subjects with mild cognitive impairment (MCI) and in those transitioning from healthy to MCI. Conclusion Our findings are consistent with a number of published plasma Aβ studies and, although the prognostic value of individual measures in any given subject is limited, the diagnostic contribution of plasma Aβ may demonstrate utility when combined with a panel of peripheral biomarkers.