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Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future
Author(s) -
Geda Yonas E.,
Schneider Lon S.,
Gitlin Laura N.,
Miller David S.,
Smith Gwenn S.,
Bell Joanne,
Evans Jovier,
Lee Michael,
Porsteinsson Anton,
Lanctôt Krista L.,
Rosenberg Paul B.,
Sultzer David L.,
Francis Paul T.,
Brodaty Henry,
Padala Prasad P.,
Onyike Chiadikaobi U.,
Ortiz Luis Agüera,
AncoliIsrael Sonia,
Bliwise Donald L.,
Martin Jennifer L.,
Vitiello Michael V.,
Yaffe Kristine,
Zee Phyllis C.,
Herrmann Nathan,
Sweet Robert A.,
Ballard Clive,
Khin Ni A.,
Alfaro Cara,
Murray Patrick S.,
Schultz Susan,
Lyketsos Constantine G.
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.12.001
Subject(s) - apathy , anticipation (artificial intelligence) , distress , psychology , psychiatry , disease , depression (economics) , psychosis , dementia , psychotherapist , cognition , medicine , pathology , artificial intelligence , computer science , economics , macroeconomics
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS‐PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome‐specific synthetic reviews and recommendations prepared by NPS‐PIA workgroups on depression, apathy, sleep, agitation, and psychosis.