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Focal hemosiderin deposits and β‐amyloid load in the ADNI cohort
Author(s) -
Kantarci Kejal,
Gunter Jeffrey L.,
Tosakulwong Nirubol,
Weigand Stephen D.,
Senjem Matthew S.,
Petersen Ronald C.,
Aisen Paul S.,
Jagust William J.,
Weiner Michael W.,
Jack Clifford R.
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.10.011
Subject(s) - hemosiderin , amyloid (mycology) , cohort , medicine , pathology
Background Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid‐modifying trials for treatment and prevention of Alzheimer's disease (AD). Methods Subjects were cognitively normal ( n = 171), early‐mild cognitive impairment (MCI) ( n = 240), late‐MCI ( n = 111), and AD ( n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β‐amyloid load was assessed with 18 F‐florbetapir positron emission tomography. Results Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age ( P < .001) and β‐amyloid load ( P < .001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow‐up (rank correlation = 0.49; P < .001). Conclusions Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β‐amyloid load.