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P2‐273: Can memory profiling predict progression to Alzheimer's disease in amnestic mild cognitive impairment?
Author(s) -
Jones Andrew,
Graham Petra,
Ellis Kathryn,
Ames David,
Savage Greg
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.981
Subject(s) - neuropsychology , psychology , dementia , audiology , cognitive impairment , disease , recall , cognition , memory impairment , neuropsychological assessment , context (archaeology) , medicine , psychiatry , cognitive psychology , paleontology , biology
12, 8.5% with 13-15, and 10.2% with 16+ years. Using normative data adjusted for age, education, sex, and ethnicity reduces, but does not eliminate, the prevalence of low scores in adults with below average intelligence.Conclusions: Current guidelines and recommendations for MCI either do not explicitly define the psychometric criteria for defining memory impairment, or they recommend applying a cutoff score of 1.5 standard deviations below ageand education-adjusted normative data. False positive diagnoses in high functioning older adults, and false negative diagnoses in low functioning people, can be reduced by refining the psychometric criteria for MCI based on the number of tests administered and the level of intelligence of the patient.