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P2‐257: Verbal fluency tests: Sensitivity to disease or drug effects not affected by simplifying scoring
Author(s) -
Veroff Amy,
Snyder Peter,
Fredrickson Amy,
Pietrzak Robert,
Gale Joanne,
Maruff Paul
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.965
Subject(s) - verbal fluency test , fluency , audiology , psychology , neuropsychology , placebo , normative , neuropsychological assessment , test (biology) , cognition , clinical psychology , medicine , psychiatry , paleontology , philosophy , mathematics education , alternative medicine , epistemology , pathology , biology
imaging was conducted followingz 12 mCi of [11 C] PIB and 60 min dynamic PET scan in 3D mode (septa retracted). Mean cortical binding potential (MCBP) was determined as previously described. Results: Pearson correlation revealed the following correlations and trends between MCBP (for amyloid) and hippocampal subvolumes: left CA2-3 r 1⁄4 -0.29 (p 1⁄4 0.05); right CA2-3 r1⁄4 -0.25 (p1⁄4 0.09); left CA1 r1⁄4 -0.20 (p1⁄4 0.18); right CA1 r 1⁄4 -0.27 (p 1⁄4 0.07). No other regional volumes were correlated with MCBP. Conclusions: In this young healthy cognitively normal population there were trends towards the same pattern seen recently in an amnestic MCI population, with significantly smaller subfield volumes in CA 2-3 and subiculum compared with controls. In our study group only 8/46 participants had elevated MCBP (> 0.18 BP). We will extend our sample to a larger and older population, which can be expected to have higher numbers of participants with elevated amyloid.