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P2‐224: Structural differences in cognitively normal elderly individuals with abnormal amyloid biomarkers: Detection using volumetric MRI in ADNI and AIBL
Author(s) -
Gray Katherine,
Wolz Robin,
Heckemann Rolf,
Rueckert Daniel,
Hammers Alexander
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.931
Subject(s) - neuroimaging , alzheimer's disease neuroimaging initiative , medicine , neurodegeneration , disease , dementia , pathological , insula , psychology , pathology , oncology , neuroscience , psychiatry
creasedmiddle frontal and inferior fronto-opercular SN connectivity was associated with poorer processing speed, fluid reasoning and working memory. Conclusions: High Ab in healthy adults is associated with decreased connectivity in DMN and enhanced connectivity in SN. There was a direct relationship between Ab-induced DMN connectivity decreases and cognitive performance, but an inverse relationship for Ab-induced SN connectivity increases.