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P2‐223: The usefulness of an optimal diffusion‐weighted imaging protocol for lesion detection in transient global amnesia
Author(s) -
Kim JungEun,
Kwon Yooseok,
Yang Youngsoon,
Baek Min Jae,
Kim SangYun
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.930
Subject(s) - transient global amnesia , lesion , medicine , magnetic resonance imaging , diffusion mri , radiology , nuclear medicine , amnesia , pathology , psychiatry
ume. Baseline ventricle volume (average 6 SEM) was 35.3 6 2.7 cm 3 for normal elderly, 46.0 6 6.3 cm 3 for MCI and 50.3 6 6.5 cm 3 for AD. A significant ventricle volume increase was detected over 24 months in MCI (P <0.001) and AD subjects (P <0.001), but not in normal elderly (P 1⁄4 0.12). The incorporation of the EM segmentation increased ventricle volume by 5-6% due to inclusion of the temporal horn regions and increased the observed 24 month differences within groups by 22-90%. Conclusions: By combining a texture-based approach that is optimal for capturing the ventricle body and a shape-based approach that is optimal for capturing thin horn details, ventricle segmentation accuracy was maximized increasing overall sensitivity to change. Such an algorithm could assist with early diagnosis and increase the efficiency of the evaluation of new drugs in clinical trials.