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P2‐208: Cortical thinning in early‐stage and late‐stage amnestic mild cognitive impairment
Author(s) -
Ye Byoung Seok,
Kim Geon Ha,
Cho Hanna,
Shin Ji Soo,
Noh Young,
Na Duk L.,
Seo Sang Won
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.915
Subject(s) - temporal lobe , dementia , psychology , posterior cingulate , cognitive impairment , neuroscience , neuropsychology , posterior parietal cortex , parietal lobe , cortex (anatomy) , memory impairment , audiology , medicine , cognition , disease , epilepsy
(GM) density in right inferior parietal lobule, lower CDR-SOB score, and lower mini-mental state examination (MMSE) score. The ApoE genotyping and CERAD neuropsychological tests except MMSE, and fractional anisotropy (FA) and mean diffusivity (MD) values derived from DTI were not significantly different between MCIc and MCInc. In terms of AD prediction after two-years in MCI, logistic regression analyses showed that the combination model including right inferior parietal lobule density on MRI and MMSE score (accuracy: 87.5%) was significantly better than any other models. Conclusions: The combination of GM density information on MRI and global cognitive score is probably the most cost-effective model to predict AD in MCI patients after a two-year follow-up period.