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P2‐186: Low BMI predicts incident Alzheimer's disease in older adults with amnestic mild cognitive impairment: A three‐year prospective cohort study
Author(s) -
Chu Leungwing
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.892
Subject(s) - medicine , prospective cohort study , body mass index , cohort , cohort study , disease , apolipoprotein e , alzheimer's disease , gerontology
Background: There is a high frequency of the risk-conferring APOE-e4 allele in African populations, but the risk ratio of dementia is less than in Europeans. In an admixed population of older Cubans I estimate the prevalence, incidence, correlates and impact of dementia among older Cubans; to assess the effects of reported ethnicity, admixture and apolipoprotein E genotype on dementia prevalence and to estimate the association between cardiovascular risk factors and dementia incidence Methods:We undertook a one phase survey of all over 65 year old residents of seven catchment areas in Cuba (n 1⁄4 2944) during 2003 to 2007. Dementia diagnosis was established according to DSM-IV and 10/66 criteria. APOE genotype was determined in 2520 participants, and genetic admixture in 235 dementia cases and 349 controls. An incidence wave was conducted 4.5 years after cohort inception. The cohort for the analyses of dementia incidence was defined as all those who were free of any dementia (either DSM-IV or 10/66 dementia) at baseline . The protocols used in the baseline and the follow up wave were identical for the ascertainment of dementia status, and very similar in other respects. Results:We undertook a one phase survey of all over 65 year old residents of seven catchment areas in Cuba (n 1⁄4 2944) during 2003 to 2007. Dementia diagnosis was established according to DSM-IV and 10/66 criteria. APOE genotype was determined in 2520 participants, and genetic admixture in 235 dementia cases and 349 controls. An incidence wave was conducted 4.5 years after cohort inception. The cohort for the analyses of dementia incidence was defined as all those who were free of any dementia (either DSM-IV or 10/66 dementia) at baseline. The protocols used in the baseline and the follow up wave were identical for the ascertainment of dementia status, and very similar in other respects. Conclusions: The prevalence and incidence of dementia in Cuba is similar to developed countries. No support for the hypotheses that genes linked to admixture may reduce the risk for dementia among Africans, or modify the effect of APOE genotype. Counter to our hypothesis, African admixture may be associated with higher risk of dementia.