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P2‐174: Attributable risk of mortality from incident Alzheimer's disease
Author(s) -
James Bryan,
Leurgans Sue,
Bennett David
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.880
Subject(s) - medicine , dementia , hazard ratio , proportional hazards model , demography , cohort , cohort study , population , gerontology , longitudinal study , prospective cohort study , relative risk , disease , confidence interval , environmental health , pathology , sociology
tracking with improved performance on verbal learning (<0.05) while higher low-density lipoprotein (LDL) was associated with lower performance on composite episodic memory. Those healthy participants who had higher PROCAM scores had statistically significant lower cognitive performance on composite episodic memory (<0.05).Conclusions: Vascular factors have an important role in the clinical manifestation of cognitive disease. This study examines a combined cohort of 939 Australians who underwent full cognitive testing and vascular risk profile and had normal cognition. Even in the normal cognitive range of performance, vascular risk presents a significant influence on cognitive performance. Further work examining the follow-up of these 938 individuals at repeat testing is currently underway.