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P2‐063: Comparison of protein concentrations in serum versus plasma from Alzheimer's patients
Author(s) -
Barber Robert,
Xiao Guanghua,
Wilhelmsen Kirk,
Huebinger Ryan,
DiazArrastia Ramon,
O'Bryant Sid
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.767
Subject(s) - biomarker , blood proteins , medicine , alzheimer's disease , disease , blood plasma , endocrinology , chemistry , oncology , biochemistry
Background: There is great interest in developing blood-based biomarkers for Alzheimer’s disease (AD); however, there is no consensus as to what blood fraction is most appropriate for analyzing particular markers. The current study provides empirical evidence regarding how bloodbased proteins vary depending on whether they are assayed in serum or plasma. Methods: We analyzed concentrations of 100 proteins in matched samples of serum and plasma from 39 Caucasian AD participants from the Texas Alzheimer’s Research and Care Consortium by multiplex immunoassay. Results: Concentrations of 40 proteins were highly correlated (r 2 ≥ 0.75)