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P2‐020: Variability in blood‐based beta‐amyloid assays: The need for consensus on preanalytical processing
Author(s) -
Watt Andrew,
Perez Keyla,
Rembach Alan,
Masters Colin,
Villemagne Victor,
Barnham Kevin
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.723
Subject(s) - medicine , population , disease , protocol (science) , intensive care medicine , sample (material) , neuroimaging , molecular diagnostics , bioinformatics , pathology , psychiatry , environmental health , alternative medicine , biology , chemistry , chromatography
analysis of peripheral blood plasma biomarkers of Ab40, Ab42, IL-10, TTau, P-Tau181 and IL-6 concentration. Results: One-way ANOVA analysis of Ab40 and IL-10 had statistically significant difference among three groups (P <0.001 and P 1⁄4 0.020). With Ab40 42.70 as the cutoff point, the ability of discriminating between AD and NC was sensitivity 80.0, specificity 69.6. Conclusions: The blood plasma Ab40 had the ability to distinguish between AD and NC. The results of plasma biomarkers in present research cannot distinguish between aMCI and NC.