P2‐011: Microglia activation in the Alzheimer's brain: Normalization by Posiphen® | Zendy

Maccecchini Maria | Zendy; Zhang Jing | Zendy; Zetterberg Henrik | Zendy

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P2‐011: Microglia activation in the Alzheimer's brain: Normalization by Posiphen®

Author(s) -

Maccecchini Maria,

Zhang Jing,

Zetterberg Henrik

Publication year - 2012

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2012.05.714

Subject(s) - microglia , proinflammatory cytokine , neuroprotection , neuroinflammation , inflammation , medicine , central nervous system , innate immune system , immune system , immunology , neuroscience , biology

sera of MCI and AD patients in contrast to the controls, suggest an underlying inflammatory process linked to neurodegeneration. However, the pro-inflammatory response appears to partially subside in patients with AD, as they have lower the levels of circulating IL-8 (chemotractant for neutrophils) and MIP1b (secreted by cytotoxic CD8+ T lymphocytes) when compared to MCI. Overall, the present work presents evidence for the potential of IL-8 and MIP-1b as biological markers to distinguish MCI from early stage AD.

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