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P2‐011: Microglia activation in the Alzheimer's brain: Normalization by Posiphen®
Author(s) -
Maccecchini Maria,
Zhang Jing,
Zetterberg Henrik
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.714
Subject(s) - microglia , proinflammatory cytokine , neuroprotection , neuroinflammation , inflammation , medicine , central nervous system , innate immune system , immune system , immunology , neuroscience , biology
sera of MCI and AD patients in contrast to the controls, suggest an underlying inflammatory process linked to neurodegeneration. However, the pro-inflammatory response appears to partially subside in patients with AD, as they have lower the levels of circulating IL-8 (chemotractant for neutrophils) and MIP1b (secreted by cytotoxic CD8+ T lymphocytes) when compared to MCI. Overall, the present work presents evidence for the potential of IL-8 and MIP-1b as biological markers to distinguish MCI from early stage AD.