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O2‐09‐03: Endoplasmic reticulum stress links impaired insulin signaling and Alzheimer's disease
Author(s) -
Lourenço Mychael,
Silva Cesar,
Sathler Luciana,
FornyGermano Leticia,
Bomfim Theresa,
Araújo Sheila,
CampelloCosta Paula,
Klein William,
Muñoz Douglas,
Ferreira Sergio,
De Felice Fernanda
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.674
Subject(s) - unfolded protein response , endoplasmic reticulum , insulin receptor , neuroprotection , endocrinology , insulin resistance , medicine , biology , signal transduction , microbiology and biotechnology , insulin
translocation of Beclin1-Vps34 to form a constitutional complex with enhanced lipid kinase activity for generating omegasomes. Also, sequestration of p62, the ubiquitinand LC3-binding protein, at the ER aggregation site may facilitate aggregated ER membrane or proteins to autophagic degradation. Conclusions: This is among the first study to demonstrate that aggregation of the ER promotes the formation of Atg14L-Beclin1-Vps34 complex to initiate autophagy. In addition p62 on the ER further promote clearance of damaged ER for autophagic degradation.