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O2‐06‐03: Identification of non‐invasive screening variables for the prediction of amyloid accumulation in a population‐based study of cognitively normal elderly individuals
Author(s) -
Mielke Michelle,
Wiste Heather,
Wiegand Stephen,
Knopman David,
Lowe Val,
Roberts Rosebud,
SwensonDravis Dana,
Boeve Bradley,
Geda Yonas,
Senjem Mathew,
Vemuri Prashanthi,
Petersen Ronald,
Jack Clifford
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.656
Subject(s) - logistic regression , medicine , receiver operating characteristic , population , odds ratio , univariate , sample size determination , univariate analysis , multivariate statistics , multivariate analysis , statistics , mathematics , environmental health
ginal (P <0.003) and precuneus (P <10-5) (Figure 1). Greater decreases in metabolism were seen in CDR> 1⁄4 1 subjects in a similar set of regions (P <10-5). Significant negative associations of FDG metabolism with age, controlling for CDR group, were also seen in these regions (P <0.04). While lower mean regional FDG uptake in CDR0 carriers compared to non-carriers did not reach statistical significance, there was a significant inverse relation between TFAO and carrier FDG uptake measured in an AD-vulnerable aggregate region (P <0.05) and in the angular gyrus (P <0.05) (Figure 2). Conclusions: In symptomatic DIAN participants, FDG metabolism was reduced in a regional pattern similar to sporadic AD. In asymptomatic mutation carriers, a similar pattern of FDG hypometabolism was associated with increasing proximity to their family’s median age of symptom onset.