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O2‐06‐01: Disrupted functional connectivity in autosomal dominant Alzheimer's disease: Preliminary findings from the DIAN study
Author(s) -
Chhatwal Jasmeer,
Schultz Aaron,
Johnson Keith,
Benzinger Tammie,
Jack Clifford,
Salloway Stephen,
Ringman John,
Koeppe Robert,
Marcus Daniel,
Thompson Paul,
Saykin Andrew,
Correia Stephen,
Schofield Peter,
Rowe Christopher,
Fox Nick,
Brickman Adam,
Mayeux Richard,
Mathis Chester,
Weiner Michael,
Fagan Anne,
Goate Alison,
Cairns Nigel,
Xiong Chengjie,
Masters Colin,
Ghetti Bernardino,
Moulder Krista,
Martins Ralph,
Bateman Randall,
Buckles Virginia,
Morris John,
Sperling Reisa
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.654
Subject(s) - default mode network , clinical dementia rating , posterior cingulate , precuneus , presenilin , cohort , early onset alzheimer's disease , medicine , dementia , alzheimer's disease , asymptomatic carrier , asymptomatic , neuroscience , psychology , disease , functional connectivity , functional magnetic resonance imaging
AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE: PRELIMINARY FINDINGS FROM THE DIAN STUDY Jasmeer Chhatwal1, Aaron Schultz2, Keith Johnson1, Tammie Benzinger3, Clifford Jack4, Stephen Salloway5, John Ringman6, Robert Koeppe7, Daniel Marcus3, Paul Thompson8, Andrew Saykin9, Stephen Correia5, Peter Schofield10, Christopher Rowe11, Nick Fox12, Adam Brickman13, Richard Mayeux13, Chester Mathis14, Michael Weiner15, Anne Fagan3, Alison Goate3, Nigel Cairns3, Chengjie Xiong3, Colin Masters16, Bernardino Ghetti9, Krista Moulder3, Ralph Martins17, Randall Bateman3, Virginia Buckles3, John Morris3, Reisa Sperling18, 1Massachusetts General Hospital, Boston, Massachusetts, United States; 2Massachusetts General Hospital, Charlestown, Massachusetts, United States; 3Washington University School of Medicine, St. Louis, Missouri, United States; 4Mayo Clinic, Rochester, Minnesota, United States; 5Brown University, Providence, Rhode Island, United States; 6UCLA Department of Neurology, Los Angeles, California, United States; 7University of Michigan, Ann Arbor, Michigan, United States; 8UCLA School of Medicine, Los Angeles, California, United States; 9Indiana University School of Medicine, Indianapolis, Indiana, United States; 10Prince of Wales Medical Research Institute, Randwick-Sydney, Australia; 11Austin Health, Melbourne, Australia; 12Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom; 13Columbia University, New York, New York, United States; 14University of Pittsburgh, Pittsburgh, Pennsylvania, United States; 15UCSF, San Francisco, California, United States; 16The University of Melbourne, Melbourne, VIC, Australia; 17Edith Cowan University, Perth, Australia; 18Brigham and Women’s Hospital, Boston, Massachusetts, United States. Background: Decreases in the functional connectivity of the default mode network (DMN) have been observed in sporadic, late-onset Alzheimer’s Disease (AD) and in amyloid-positive clinically normal