O2‐05‐05: PPAR‐gamma activation with AT1 receptor blockade prevents blood‐brain barrier disruption and cognitive impairment in type 2 diabetic mellitus mice | Zendy

Mogi Masaki | Zendy; Min LiJuan | Zendy; Iwanami Jun | Zendy; Tsukuda Kana | Zendy; Horiuchi Masatsugu | Zendy

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O2‐05‐05: PPAR‐gamma activation with AT1 receptor blockade prevents blood‐brain barrier disruption and cognitive impairment in type 2 diabetic mellitus mice

Author(s) -

Mogi Masaki,

Min LiJuan,

Iwanami Jun,

Tsukuda Kana,

Horiuchi Masatsugu

Publication year - 2012

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2012.05.652

Subject(s) - morris water navigation task , telmisartan , extravasation , medicine , endocrinology , evans blue , blood–brain barrier , angiotensin ii receptor type 1 , cognitive decline , hippocampus , angiotensin ii , type 2 diabetes mellitus , behavioural despair test , diabetes mellitus , receptor , pathology , blood pressure , dementia , disease , antidepressant , central nervous system

davunetide’s ability to restore axonal transport in mice exposed to colchicine. These data support previous reports that davunetide’s neuroprotective effect is mediated through microtubule stabilization. Restoration of axonal transport suggests clinical utility in various neurological conditions characterized by axonal transport impairment. We thank Drs. Michael Gold, Bruce Morimoto and Alistair Stewart, Allon Therapeutics Inc. for excellent suggestions.

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