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O2‐05‐05: PPAR‐gamma activation with AT1 receptor blockade prevents blood‐brain barrier disruption and cognitive impairment in type 2 diabetic mellitus mice
Author(s) -
Mogi Masaki,
Min LiJuan,
Iwanami Jun,
Tsukuda Kana,
Horiuchi Masatsugu
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.652
Subject(s) - morris water navigation task , telmisartan , extravasation , medicine , evans blue , endocrinology , blood–brain barrier , angiotensin ii receptor type 1 , hippocampus , cognitive decline , type 2 diabetes mellitus , angiotensin ii , diabetes mellitus , receptor , pathology , central nervous system , blood pressure , dementia , disease
davunetide’s ability to restore axonal transport in mice exposed to colchicine. These data support previous reports that davunetide’s neuroprotective effect is mediated through microtubule stabilization. Restoration of axonal transport suggests clinical utility in various neurological conditions characterized by axonal transport impairment. We thank Drs. Michael Gold, Bruce Morimoto and Alistair Stewart, Allon Therapeutics Inc. for excellent suggestions.