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P1‐289: Anxiety state and memory abilities in rodent models of successful aging: The free‐feeding Lou/C/Jall rat and calorie‐restricted Sprague Dawley rat
Author(s) -
Menard Caroline,
Quirion Rémi,
Ferland Guylaine,
Gaudreau Pierrette
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.569
Subject(s) - open field , elevated plus maze , morris water navigation task , calorie restriction , medicine , endocrinology , psychology , thigmotaxis , anxiety , rodent , calorie , physiology , hippocampus , biology , psychiatry , ecology
in the olfactory system, and that functional recovery correlates with the restoration of detailed circuit organization. These results show that basic function can be restored even with imperfect wiring and that the degree of wiring precision may be used to gauge the level of recovery, and as a measure to determine efficacy of potential treatments. This in vivomodel thus provides a broad platform to study APP-induced circuit disruption and repair within a precisely defined network.