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P1‐276: An integrated mechanistic model to interrelate CSF Aβ40, Aβ42, sAPPβ and sAPPα response to β‐ and γ‐secretase inhibitors in rhesus monkey
Author(s) -
Stone Julie,
Maanen Eline,
Ahsman Maurice,
Steeg Tamara,
Savage Mary,
Michener Maria S.,
Kleijn Huub Jan
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.556
Subject(s) - biomarker , pharmacology , cerebrospinal fluid , amyloid precursor protein , nonmem , amyloid precursor protein secretase , chemistry , pharmacokinetics , medicine , neuroscience , biology , biochemistry , alzheimer's disease , disease