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P1‐225: A study to evaluate the pharmacokinetics and pharmacodynamics of single and multiple oral doses of the novel BACE inhibitor MK‐8931 in Japanese subjects
Author(s) -
Min K.,
Forman Mark,
Dockendorf Marissa,
Palcza John,
Soni Peter,
Ma Lei,
Krishna Gopal,
Hodsman Peter,
Masuo Kazuko,
Tanen Michael,
Wagner John,
Troyer Matthew
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.504
Subject(s) - tolerability , pharmacokinetics , pharmacodynamics , medicine , placebo , cohort , adverse effect , pharmacology , gastroenterology , pathology , alternative medicine
loid in the cerebral cortex (P 1⁄4 0.0001) and corpus callosum (P 1⁄4 0.001). In addition, the TBI rats treated with estrone had reduced cortical lesion volume and cortical levels of TUNEL + staining (w80%). Conclusions: Estrone given acutely after brain injury decreases cortical neuronal cell death and white matter injury. These results suggest that other estrogens in addition to estradiol may afford individuals protection secondary brain injury after TBI.