P1‐209: Cognitive decline in Asian patients with CADASIL

in Buenos Aires, Argentina. Methods:Demographic data and cognitive, behavioral, functional and QoL scales completed by 77 patients and their caregivers were analyzed using one-way ANOVA, paired samples and multivariate correlations, at baseline and at the end of the CR program. Results: In terms of the etiology of ABD, 57.2% of the patients had stroke, 23.4% TBI and 19.4 % other causes of brain injury. The age of the patients was (mean, SD) 50.10 6 18.71 years, education 13.92 6 3.36 years, initial Mini Mental State Examination 25.89 6 3.75 and number of CR sessions 28.44 6 8.75.After the CR program, improvements in patient QoL (-4.2; p:0.01), depressive symptoms (1.7; p:0.01) and subjective memory (P <0.05) were noted. Based on caregiver feedback, there was also an improvement in patient basic (-1.3; p:0.02) and instrumental ADL (1.4; p0.02) scores. No significant changes in CB or other behavioral scales were noted. Conclusions: In this prospective study of patients with ABD who followed an outpatient CR program, improvements were noted in clinically relevant outcomes as QoL and functional scales. These are the preliminary results of an ongoing larger scale population study.