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P1‐165: Tau immunotherapy improves axonal transport as detected in vivo by manganese‐enhanced magnetic resonance imaging
Author(s) -
Little Benjamin,
Khan Umer,
Bertrand Anne,
Rajamohamedsait Hameetha,
Hill Lindsay,
Hoang Dung Minh,
Wadghiri Youssef Zaim,
Sigurdsson Einar M.
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.443
Subject(s) - magnetic resonance imaging , immunotherapy , medicine , in vivo , tau protein , pathology , nuclear medicine , biology , radiology , disease , cancer , microbiology and biotechnology , alzheimer's disease
increased VRF was similar to that in preclinical AD with exception with the more severely affected CA3&DG. Elevated SBP and TChol were associated with volume loss in CA3&DG while CA1 and CA1-2transition were influenced by SBP respectively TChol. The selective vulnerability of these subfields for hypertension/hyperlipidemia is consistent with that described in animal models and autopsy studies. Their usefulness for diagnostic purposes has to be further investigated.