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P1‐158: Infarctions on antemortem MRI are associated with the presence of microinfarcts at autopsy
Author(s) -
Raman Mekala,
Preboske Gregory,
Przybelski Scott,
Senjem Mathew,
Murphy Matthew,
Murray Melissa,
Boeve Bradley,
Knopman David,
Petersen Ronald,
Parisi Joseph,
Dickson Dennis,
Jack Clifford,
Kantarci Kejal
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.436
Subject(s) - autopsy , fluid attenuated inversion recovery , medicine , hyperintensity , magnetic resonance imaging , white matter , dementia , postmortem studies , pathology , radiology , disease
The mean and standard deviation of the texture-based marker was for controls -0.360 6 0.648, for MCI 0.101 6 0.950, and for AD 1.021 6 1.117. Normal controls and AD as well as MCI and AD were separable from each other according to the rank sum test (P<0.001 for both) whereas normal controls andMCI were not separable (P1⁄4 0.082). The separation of the AD group maintained significance after adjusting for hippocampal volume (P 1⁄4 0.003 and P 1⁄4 0.011). Conclusions: A novel texture-based MRI marker was able to discriminate between both normal controls and AD, and MCI and AD, even after adjusting for the diagnostic power of volume, demonstrating that hippocampal MRI Texture was related to cognition. The marker, relying on textural information extracted directly from the tissue, may complement existing MRI makers targeting atrophy.