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P1‐130: Mild cognitive impairment: Determinant patterns of short and long time to incident dementia
Author(s) -
Luck Tobias,
Luppa Melanie,
Wiese Birgit,
Breitner John,
Scherer Martin,
Maier Wolfgang,
RiedelHeller Steffi
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.407
Subject(s) - dementia , longitudinal study , proportional hazards model , cognition , medicine , cognitive impairment , gerontology , cognitive decline , psychology , audiology , pediatrics , psychiatry , disease , pathology
rospective cohorts from the Penn Memory Center database NC (199) and C (342). Cognitive performance was measured by the Cogstate Computerized Program (R) or the CERAD Total (NC, C). The sensitivity, specificity and area under the Receiver Operator Characteristic (ROC) curve were utilized to derive cut-off scores that distinguished normal from the abnormal groups on the CERAD, CogState and Prospective RetrospectiveMemory Questionnaire (PRMQ), a measure of subjective memory complaints.Results:Aprospective cohort study enrolled 125 community dwelling adults age >65 and cognitively unimpaired. These PC subjects were compared to 2 retrospective cohorts from the Penn Memory Center database NC (199) and C (342). Cognitive performance was measured by the Cogstate Computerized Program (R) or the CERAD Total (NC, C). The sensitivity, specificity and area under the Receiver Operator Characteristic (ROC) curve were utilized to derive cut-off scores that distinguished normal from the abnormal groups on the CERAD, CogState and Prospective Retrospective Memory Questionnaire (PRMQ), a measure of subjective memory complaints. Conclusions: This study confirms previous work (psychopathology, education and personality). Focus of Presentation: Subjective memory complaints and leisure behavior as associated cognitive performance.