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P1‐129: Physical activity and cognitive stimulation improve cognition and alter levels of plasma beta‐amyloid in healthy elderly
Author(s) -
Shah Tejal,
Verdile Giuseppe,
Sohrabi Hamid,
Martins Ralph
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.406
Subject(s) - cognition , medicine , neuropsychology , psychology , cognitive decline , physical therapy , dementia , psychiatry , disease
rospective cohorts from the Penn Memory Center database NC (199) and C (342). Cognitive performance was measured by the Cogstate Computerized Program (R) or the CERAD Total (NC, C). The sensitivity, specificity and area under the Receiver Operator Characteristic (ROC) curve were utilized to derive cut-off scores that distinguished normal from the abnormal groups on the CERAD, CogState and Prospective RetrospectiveMemory Questionnaire (PRMQ), a measure of subjective memory complaints.Results:Aprospective cohort study enrolled 125 community dwelling adults age >65 and cognitively unimpaired. These PC subjects were compared to 2 retrospective cohorts from the Penn Memory Center database NC (199) and C (342). Cognitive performance was measured by the Cogstate Computerized Program (R) or the CERAD Total (NC, C). The sensitivity, specificity and area under the Receiver Operator Characteristic (ROC) curve were utilized to derive cut-off scores that distinguished normal from the abnormal groups on the CERAD, CogState and Prospective Retrospective Memory Questionnaire (PRMQ), a measure of subjective memory complaints. Conclusions: This study confirms previous work (psychopathology, education and personality). Focus of Presentation: Subjective memory complaints and leisure behavior as associated cognitive performance.