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P1‐074: The Dementia Severity Rating Scale for dementia: Relationships with the CDR sum of boxes, clinical diagnosis and CSF biomarkers
Author(s) -
Moelter Stephen,
Glenn Megan,
Xie Sharon Xiangwen,
Chittams Jesse,
Arnold Steven,
Clark Christopher
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.350
Subject(s) - clinical dementia rating , dementia , receiver operating characteristic , medicine , biomarker , area under the curve , linear regression , rating scale , psychology , disease , statistics , developmental psychology , biochemistry , chemistry , mathematics
that these changes in velocity and variability were not simply age-related. Conclusions: Cognitive impairment is characterized not only by memory loss, but also by functional impairment. Using quantitative gait analysis with dual task paradigms, we show that gait becomes slower and more variable as cognitive decline progresses. Particularly, gait cycle time variability increases during cognitive dual tasking compared to normal walking in thosewithMCI andmild AD. Early detection of these mobility impairments may be used as a tool to aid diagnosis of those in the earliest stages of cognitive impairment.