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P1‐014: Reduced platelet amyloid precursor protein ratio (APP ratio) predicts conversion from mild cognitive impairment to Alzheimer's disease
Author(s) -
Zainaghi Isis,
Talib Leda,
Diniz Breno,
Forlenza Orestes,
Gattaz Wagner
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.289
Subject(s) - dementia , biomarker , cognitive impairment , alzheimer's disease , medicine , disease , amyloid precursor protein , oncology , cognitive decline , psychology , biology , biochemistry
However, AD patients in advanced clinical stage, as determined by low MMSE score ( 20), had lower BACE1 activity and sAPP 6 , sAPPb and Ab40 concentrations than patients with higher MMSE score. Conclusions: Our results highlight the strong diagnostic power of the core CSF biomarkers for AD. We also suggest that BACE1 activity and sAPP6 , sAPPb and Ab40 concentrations may be related to the severity of the disease.