Premium
P1‐011: Donepezil treatment's late effects on cytokines release from lymphocytes of Alzheimer's disease patients
Author(s) -
Stamouli Evaggelia,
Piperi Christina,
Katirtzoglou Everina,
Siarkos Kostantinos,
Passa Maria,
Maillis Antonis,
Papadimitriou George,
Politis Antonis
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.286
Subject(s) - medicine , cytokine , pathogenesis , proinflammatory cytokine , immune system , peripheral blood mononuclear cell , immunology , tumor necrosis factor alpha , inflammation , disease , donepezil , cholinergic , dementia , biology , biochemistry , in vitro
Imaging, Biomarkers and Lifestyle (AIBL) Longitudinal Study of Ageing using commercial Luminex 96 well assay kits. Total APOE plasma levels were then compared between non-memory complainers (NMC), subjective memory complainers (SMC), mild cognitively impaired (MCI) individuals and AD patients. The data was further compared against other collected demographics including but not limited to cerebral amyloid load as measured by positron emission tomography (PET), APOE genotype and neuropsychological scores. Results: Total protein APOE levels were significantly lower in the AD cohort, as compared to both the NMC and SMC groups. No significant correlation was found, at this time, between APOE levels and cerebral amyloid beta load, however, further analysis will determine the relationship between plasma APOE and plasma Ab levels. Significant differences in plasma APOE levels were observed between different genotypes as well. In general, those with the E4/E4 genotype have the lowest levels of plasma APOE. Conclusions: APOE shows great promise as an AD biomarker for the future development of an AD diagnostic assay with its altered protein levels between AD and control participant groups. Completed measurements of baseline plasma samples from the same individuals will add great value to this study, by analysing the changes in plasma APOE over time. The significance of these findings can be determined further as the AIBL longitudinal study of ageing continues.