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O1‐08‐06: Refining exercise prescription to promote executive functions in older adults using multistate transition modeling
Author(s) -
Fallah Nader,
Hsu Chun Liang,
Bolandzadeh Niousha,
Beattie B. Lynn,
Graf Peter,
LiuAmbrose Teresa
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.250
Subject(s) - stroop effect , cognition , executive functions , effects of sleep deprivation on cognitive performance , dementia , psychology , cognitive decline , cognitive training , cognitive remediation therapy , physical medicine and rehabilitation , medicine , psychiatry , disease , pathology
the relationship between clinical gait and cognition in a community-based sample of people aged 75 and older. Methods: Five hundred and twenty five subjects participated among the 1,374 members of the population aged 75 years and older in Kurihara and Osaki, Japan and 164 underwent volumetric magnetic resonance imaging. Our database comprised participant demographics, medical history and current symptoms, general medical examination, neurological examination, MRIs, laboratory tests, electrocardiograms, various neuropsychological tests including theMini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR). Gait function was assessed using clinical gait measures including gait pattern, gait velocity, and stride length. Gait patterns were classified as normal, neurological gaits, and abnormal due to bone and joint disease such as osteoarthritis and spodylosis. We asked participants to walk 6 m at the fastest pace to measure the gait velocity and stride length. Results:We found 385 participants with normal gait pattern, 65 with neurological gait, and 73 with abnormal gait due to bone and joint disease. As for the CDR scale, 175 participants were classified as CDR 0, 287 as CDR 0.5, 44 as CDR 1, 20 as CDR 2, and 2 as CDR3. The degree of atrophy of the entorhinal cortex was significantly correlated with gait velocity. Conclusions: Gait velocity was significantly decreased as CDR rating increased. A comprehensive approach of motor as well as cognitive assessment is needed for community residents.