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P4‐099: Early‐onset familial Alzheimer's disease and the definition of family: Experience with an indigenous community
Author(s) -
Mackie Jennifer,
Brief Elana,
Butler Rachel,
Dwosh Emily,
Beattie B. Lynn,
Illes Judy
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.2178
Subject(s) - indigenous , family tree , genealogy , disease , extended family , psychology , medicine , history , biology , ecology , pathology
genotype. Conclusions: The CNR-MAJ has confirmed the molecular diagnosis in 9% of patients with sporadic early-onset AD. Moreover, the APOE4/E4 genotype could also explain additional 9% of patients. For the remaining cases, we have not found any genetical abnormality. Among them, 3 cases whose both parents are still alive and without dementia are currently enrolled in a research program to identify new genetic de novo causes involved in early-onset AD.