P4‐099: Early‐onset familial Alzheimer's disease and the definition of family: Experience with an indigenous community | Zendy

Mackie Jennifer | Zendy; Brief Elana | Zendy; Butler Rachel | Zendy; Dwosh Emily | Zendy; Beattie B. Lynn | Zendy; Illes Judy | Zendy

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P4‐099: Early‐onset familial Alzheimer's disease and the definition of family: Experience with an indigenous community

Author(s) -

Mackie Jennifer,

Brief Elana,

Butler Rachel,

Dwosh Emily,

Beattie B. Lynn,

Illes Judy

Publication year - 2012

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2012.05.2178

Subject(s) - indigenous , family tree , genealogy , disease , extended family , psychology , medicine , history , biology , ecology , pathology

genotype. Conclusions: The CNR-MAJ has confirmed the molecular diagnosis in 9% of patients with sporadic early-onset AD. Moreover, the APOE4/E4 genotype could also explain additional 9% of patients. For the remaining cases, we have not found any genetical abnormality. Among them, 3 cases whose both parents are still alive and without dementia are currently enrolled in a research program to identify new genetic de novo causes involved in early-onset AD.

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