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P2‐050: Lower serum antibodies against tau protein and heavy neurofilament in Alzheimer's disease
Author(s) -
Bartos Ales,
Fialova Lenka,
Svarcova Jana,
Ripova Daniela
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.2144
Subject(s) - antibody , neurofilament , tau protein , antigen , disease , immunology , medicine , autoantibody , alzheimer's disease , endocrinology , immunohistochemistry
The different responses to these antigens suggest some antibody selectivity in AD. The significant decline was observed for only serum anti-tau antibodies in AD patients over time and it corresponds to lower anti-tau levels in these patients. Our findings indicate a special feature of disease-relevant antigens and humoral autoimmunity in AD.