Premium
P1‐298: Memantine: Assessment in novel object recognition and quantitative 2‐deoxyglucose metabolism in rat
Author(s) -
Patel Toshal,
Papworth Jonathan,
Robertson Janette,
Groom Anthony,
Gartlon Jane,
Lucas Adam,
Syme Alexander,
Dawson Lee
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.2138
Subject(s) - memantine , nmda receptor , neuroscience , psychology , hippocampal formation , inferior colliculus , hippocampus , perirhinal cortex , chemistry , pharmacology , cognition , medicine , recognition memory , receptor , nucleus
dementia. Conclusions: Our findings indicate that following cardiac surgery the number of individuals identified as at risk of dementia is much higher than expected in the general population (0.3-0.8% per year) as more than 50% of individuals were affected. Equally concerning are the results following non-cardiac surgery and minor procedures at one year showing 13% and 18% (respectively) of individuals at risk of dementia. These results may have significant implications for clinical decision making in healthcare, and may provide a model for therapeutic intervention AD trials. References: 1 Evered, L et al. Anesth Analg 2011; 112: 1179-85, 2 Xie,Z and Tanzie, R. Exp Gerontol 2006; 41:346-59, 3 Baranov, D et al. Anesth Analg 2009; 108:1627-30, 4 Silbert et al. Anesthesiology 2006; 104: 1137-45.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom