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P4‐241: Effect of APOE‐ε4 status on the association of potential confounders and the risk of Alzheimer's disease
Author(s) -
Chen YenChing,
Tsai ChiaChih
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.2105
Subject(s) - apolipoprotein e , odds ratio , confounding , medicine , confidence interval , logistic regression , disease , diabetes mellitus , demography , gerontology , endocrinology , sociology
Background: Apolipoprotein E (APOE)-ε4 genotype has been related to significantly increased risk of late-onset Alzheimer’s disease (AD). However, 60% of AD patients are not APOE-ε4 carriers. Up to date, no study has extensively explored how APOE-ε4 modifies the associations between potential confounders and the risk of AD, especially in Asian population. Methods: A total of 287 AD patients aged 60 or older were recruited from three teaching hospitals from 2007 to 2010. Healthy controls Table 3 Effect of WMH severity on cognitive impairment according to APOE ε4 allele