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O1‐01‐04: Age‐associated trajectories of biomarkers in early‐onset Alzheimer's disease, for the Alzheimer's Prevention Initiative
Author(s) -
Chen Kewei,
Quiroz Yakeel,
Jakimovich Laura,
Gutierrez Madelyn,
Langbaum Jessica,
Roontiva Auttawut,
Thiyyagura Pradeep,
Liu Xiaofen,
Lee Wendy,
Ayutyat Napatkamon,
Nishimura Mark,
Parks Stephanie,
Alvarez Sergio,
Lopez Liliana,
AcostaBaetalia,
Fagan Anne,
Kosik Ken,
Tariot Pierre,
Reiman Eric,
Lopera Francisco
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.205
Subject(s) - biomarker , medicine , oncology , dementia , alzheimer's disease , hippocampal formation , amyloid (mycology) , age of onset , early onset alzheimer's disease , cognitive decline , cognitive impairment , disease , pathology , endocrinology , biology , genetics
showed a relation between annual change in F2-isoprostanes and cognitive decline over time for the ApoE-ε4 carriers [b(SE) -0.09(0.04), p<0.05], but not for non-carriers [b(SE) -0.05(0.05), p 1⁄4 0.3]. Conclusions: CSF F2-isoprostane levels increased over time and were related to the rate of cognitive decline only in ApoE-ε4 carriers. Our results reiterate the importance of oxidative stress in neurodegeneration, notably in patients carrying the ApoE-ε4 allele, suggesting an important relation between these factors. How this implicates therapeutic research efforts is subject for further study.