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P1‐329: Long‐term effects of subthalamic nucleus stimulation on cognition
Author(s) -
Heo JaeHyeok,
Lee KyoungMin
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.2015
Subject(s) - verbal fluency test , beck depression inventory , psychology , audiology , trail making test , boston naming test , mood , analysis of variance , cognition , subthalamic nucleus , memory span , beck anxiety inventory , repeated measures design , stroop effect , parkinson's disease , deep brain stimulation , medicine , psychiatry , neuropsychology , disease , anxiety , working memory , statistics , mathematics
Background: At present there is no cure for the common causes of dementia: Alzheimer’sand cerebrovascular-disease. Dementia may be preventable in up to 50% of cases by regular participation in multimodal physical-, socialand cognitive-activity programmes; however, most adults are not active enough. Common barriers to increased activities have been identified and may be overcome by specific psychological motivational techniques whilst the benefits from the activities can be maximised through evidence based activity design. Furthermore, activity interventions can be provided for patients with mild cognitive impairment (MCI) that are at increased risk of dementia. The ThinkingFit programme was designed to study the success of engaging patients with MCI in regular physical-, socialand cognitive-activities by making the activities fun and easily accessible. Methods: MCI participants were recruited from memory clinics and received the 12-week activity programme. The physical activity involved walking from home at an intensity of 65-75% of maximum predicted effort, 3 times a week for 30 minutes. Participants were supervised on 7 out of the expected 36 walks. The social activity took place weekly at a local facility and involved arts and crafts. Groups consisted of 8 participants to promote reinforcing group dynamics. For cognitive stimulation, participants complete 90 min/week of computer based cognitive training (www.lumosity. com). To include participants unable to travel to community centers due to disability or poor local transport, a home-based version of the activity program was provided using video teleconferencing. Results: To date, out of 193 patients screened, 78 were recruited and 74 completed the programme. High activity completion rates were recorded and responses from participants have been overwhelmingly positive: the majority would like to continue the programme in the long-term. Conclusions: High rates of recruitment can be achieved for MCI patients into intensive multimodal activity programmes, and the application of targeted motivational techniques result in high activity compliance rates. Extended periods of activity participation will be required to study the effects on dementia progression, and our results suggest it may be achievable through provision of specifically designed programmes.