Premium
P1‐318: Plasma nutrient status of Alzheimer's disease patients compared to cognitive intact elderly controls: A systematic review and meta‐analysis
Author(s) -
Lopes da Silva Sofia,
Elemans Saskia,
Kamphuis Patrick,
Sijben John,
Groenendijk Martine
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.2004
Subject(s) - meta analysis , medicine , nutrient , docosahexaenoic acid , physiology , vitamin b12 , disease , vitamin d and neurology , vitamin e , population , endocrinology , polyunsaturated fatty acid , fatty acid , environmental health , biology , biochemistry , antioxidant , ecology
Background: Epidemiological studies suggest a correlation between certain nutrients and risk of Alzheimer’s disease (AD). Several, but not all, population-based studies indicate that individuals with a high intake of n3 fatty acids, B-vitamins, or vitamin E and C have a lower risk of AD than individuals with a low intake of these nutrients. Some investigators report that AD patients have lower plasma levels of nutrients including docosahexaenoic acid (DHA), B vitamins, vitamins E and C, compared to age-matched controls. However, others do not find such differences. Methods: Therefore, we embarked on a systematic analysis to compare plasma levels of vitamins, minerals, trace elements, and fatty acids in AD patients to those in cognitive intact elderly controls, using the Preferred Reporting Items for Systematic reviews andMeta-Analyses (PRISMA)[1]. The literature published after 1990 in Cochrane Central Register of Controlled Trials, Medline, and Embase electronic databases was systematically reviewed. All reported comparisons of plasma nutrient values between AD patients and controls were integrated and summarized into a final result per nutrient using a meta-analysis regression method, correcting for differences in mean age between AD and control subjects [2]. We retrieved 3080 publications of which 78met all inclusion criteria.Results: Significant lower plasma levels of vitamin A, C, E, folate, vitamin B12, and calcium were found in AD patients compared to controls. No significant differences were observed for plasma levels of vitamin D, copper, iron, magnesium, and selenium; insufficient data were retrieved for manganese, vitamin B1, and B6 to perform the meta-analysis. Although the individual papers reported significant differences in DHA and (eicosapentaenoic acid) EPA contents of plasma fatty acids, our meta-analysis did not show this. Conclusions: To our knowledge, this is the first systematic comparison of plasma nutrient levels in AD patients to those in cognitive intact elderly controls. References: [1] Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339, b2535. [2] Sheu CF, Suzuki S (2001) Meta-analysis using linear mixed models. Behav Res Methods Instrum Comput 33, 102-107. P1-319 CEREBROSPINAL FLUID (CSF) BIOMARKERS IN ALZHEIMER’S DISEASE (AD), MILD COGNITIVELY IMPAIRED (MCI) AND AGEMATCHED HEALTHY CONTROLS (HC) FROM THE ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE (ADNI) COHORT Judith Siuciak, Eve H. Pickering, Fred Immermann, Max Kuhn, Leslie Shaw, William Potter, Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Foundation for NIH Biomarkers Consortium CSF Proteomics Project Team, Foundation for the NIH, Bethesda, Maryland, United States; 2 Pfizer Worldwide Research and Development, Groton, Connecticut, United States; University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States; Foundation for the National Institutes of Health, Bethesda, Maryland, United States; 5 ADNI, Bethesda, Maryland, United States; 6 FNIH, Bethesda, Maryland, United States.