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O5‐04‐04: MRI traits identify several loci influencing degeneration of the hippocampus lobe atrophy in the prediction of Alzheimer's disease in subjects with MCI
Author(s) -
Clerx Lies,
Rossum Ineke,
Burns Leah,
Knol Dirk,
Scheltens Philip,
Verhey F.R.J.,
Aalten Pauline,
Lapuerta Pablo,
Pol Laura,
Schijndel Ronald,
Jong Remco,
Barkhof Frederik,
Wolz Robin,
Rueckert Daniel,
Visser Pieter Jelle
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1990
Subject(s) - atrophy , cognitive decline , dementia , temporal lobe , hippocampal formation , alzheimer's disease , clinical dementia rating , medicine , cognition , psychology , audiology , disease , neuroscience , epilepsy
Age at exam (years) 75.0 (72.5-78.5) 75.9 (70.0-80.5) 73.7 (68.5-80.0) 0.78 Education (years) 14.0 (13.0-16.5) 16.0 (14.0-18.0) 15.5 (12.0-17.0) 0.06 Gender (% male) 47.8% 59% 56% 0.57 APOE4 (% APOE4 positive) 13% 55.2% 76% <0.0001 MMSE 29.0 (29.0-30.0) 27.0 (25.0-28.0) 24.0 (22.0-25.0) <0.0001 Modified ADASCog 4.8 (3.7-6.7) 11.7 (9.0-14.7) 17.7 (14.0-21.3) <0.0001 SPARE-AD -1.41 (-1.81 to -0.32) 1.2 (0.6-1.6) 1.2 (0.3-1.7) <0.0001 CSF measurements available (%) 95.7% 52.1% 92.0% Ab42 (ng/mL) 251.5 (233.0-268.0) 144.5 (125.5-189.0) 134.0 (122.0-160.0) <0.0001 T-tau (ng/mL) 56.0 (53.0-62.0) 88.5 (65.0-117.0) 112.5 (69.0-150) <0.0001 P-Tau (ng/mL) 19.5 (16.0-22.0) 33.0 (22.0-45.0) 36.5 (26.0-47.0) <0.0001 Subjects with pathological CSF 0/20 81/112 41/46 <0.0001