Premium
P4‐231: A novel approach for lowering multiple targets in Alzheimer's disease
Author(s) -
Adwan Lina,
Zawia Nasser
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1936
Subject(s) - disease , amyloid precursor protein , amyloid beta , western blot , tau protein , alzheimer's disease , neuroscience , medicine , chemistry , biology , biochemistry , gene
retention (87,5 %) rates were high. Two patients experienced knee-pain, and two falls unrelated to the intervention occurred. Patients had fewer depressive symptoms after the intervention (mean change on GDS: -1, (61); P 1⁄4 0.04). Proxy-rated QoL (-3.4 (61.7); P 1⁄4 0.002) decreased whereas patient-rated QoL did not (0.4 (62.9); P 1⁄4 0.7). SDMT score (-4.4 (64.1);P 1⁄4 0.03)) decreased indicating a worsening of mental speed and processing. PiB retention increased in all patients (pre-test: 2.60 (60.3); post-test: 2.71 (60.31); P 1⁄4 0.005), Figure. Patients and caregivers were positive towards the intervention. Conclusions: It is feasible and safe to carry out a study of moderate intensity aerobic exercise in patients with mild to moderate AD, and the intervention may decrease depressive symptoms. Decline in cognitive function and increase in PiBretention also observed is compatible with the natural history of AD. Our uncontrolled study was not designed to examine the effectiveness of aerobic exercise which must be evaluated in a large-scale randomized controlled trial.