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P4‐173: Metallomic imaging mass and optical spectrometry (MIMOS) of the murine and human eye and brain in Alzheimer's disease and normal aging
Author(s) -
Casey Noel,
Moncaster Juliet,
Minaeva Olga,
Gaudreau Amanda,
Wojnarowicz Mark,
Sarangi Srikant,
Fisher Andrew,
Tagge Chad,
Goldstein Lee
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1877
Subject(s) - human brain , medicine , pathology , chemistry , neuroscience , biology
correlation using conventional and advanced mri imaging techniques in differentiating the subtypes of progressive supranuclear palsy (PSP) i.e psp-p and psp richardson subtypes. Methods: This was a prospective study comprising of 24 patients of PSP (psp P 1⁄4 11 and psp-rs1⁄4 13) and 26 matched healthy controls. routine mri imaging and planimetry were used to diffrentiate.VBM analysis for both gray matter with t1 weighted image and white matter using DTI was performed.advanced TBSS analysis was also perfrmed and Fractionalanisotropy, mean diffusivity (MD), axial diffusivity, andradial diffusivity (RD) changes were studied in theWM of these PSP patients to identify relative severity of WM changes as well as identify spatial distribution of the differences. Clinicoradiological correlation was done to determine the strength of correlation between WM abnormalities.minerlarisation was also evaluated used r2 relaxometry. Results: The frontoparietal cerebral WM, thalamus, midbrain tectum,superior cerebellar peduncle, and cerebellar WM showed significant abnomality. Compared to PSP-P, the patients of PSP-RS had more spatial abnormalities localized to the frontal WM. Conclusions: PSP-RS showed more severe white matter abnormality compared to the PSP-P subtype.