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P4‐163: Integrative assessment of brain atrophy in Alzheimer's disease: Parallel hippocampal and thalamic atrophy
Author(s) -
Buksakowska Irena,
Szabó Nikoletta,
Horinek Daniel,
Tóth Eszter,
Hort Jakub,
Charvát František,
Vécsei László,
Rocek Miloslav,
Kinsces Tamás
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1867
Subject(s) - atrophy , voxel based morphometry , neuroscience , pathology , white matter , thalamus , hippocampal formation , medicine , brain size , psychology , magnetic resonance imaging , radiology
try(VBM) using statistical parametric mapping (SPM). Results: AD showed poorer performance of CDP, such as swaying distances, velocities and numbers of falling in unilateral stance, and medio-lateral swaying distance and velocity in sensory organization test than controls. Motor latency and antero-posterior swayingwere not different between groups. Therewere significant correlations of the performance in the unilateral stancewith frontal function tests, verbal memory and BNT. Although the cognitive status between AI+ and AIwas not different, there were gray matter atrophy in the bilateral SMA, right inferior frontal and right rectus gyrus when AI+ were compared to controls, and in left inferior frontal area when to AI(P<0.001). Conclusions: Postural instability was more prominent in AD and it was associated with gray matter atrophy in frontal and prefrontal regions responsible for attention and motor controls. We can speculate that postural instability might be an epiphenomenon of AD or be affected by the atrophy of the localized frontal areas.