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P4‐161: Age‐related differences in functional connectivity of resting‐state EEGs in Alzheimer's disease
Author(s) -
Waal Hanneke,
Straaten E.C.W.,
Haan Willem,
Scheltens Philip,
Van der Flier Wiesje,
Stam Cornelis
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1865
Subject(s) - beta (programming language) , alpha (finance) , electroencephalography , resting state fmri , functional connectivity , disconnection , audiology , alzheimer's disease , analysis of variance , psychology , disease , medicine , cardiology , neuroscience , developmental psychology , psychometrics , construct validity , computer science , political science , law , programming language
tract (CST), and right superior longitudinal fasciculus (Fig. 1). As shown by the ROI analysis (Table 1), decreased AFD was observed in all structures except the CSTwhen comparing AD vs MCI, but only in the left cingulum, uncinate, and CSTwhen comparing MCI vs healthy subjects. Conclusions: We demonstrated extensive AFD decreases in AD vs healthy subjects in white matter bundles known to be involved in language and memory. These were more extensive (particularly in the cingulum and uncinate) than have been reported using previous DWI metrics. Most of the affected regions were also different between MCI vs AD, with some regions also significant in MCI vs healthy. AFD provides improved specificity by identifying which particular WM tract is affected even in regions traversed by multiple fibre bundles (Fig. 1h&i). [1] Raffelt et al. (in press)doi:10.1016/j.neuroimage. 2011.10.045.