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IC‐P‐141: Correlation between diffusion weighted imaging‐apparent diffusion coefficient and clinical scores in mild‐to‐moderate Alzheimer's disease
Author(s) -
Bracoud Luc,
Belaroussi Boubakeur,
Lobello Kasia,
Li David,
Yu Hui Jing,
Pachai Chahin,
Wyman Bradley
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.175
Subject(s) - diffusion mri , nuclear medicine , effective diffusion coefficient , correlation , voxel , atrophy , histogram , medicine , correlation coefficient , kurtosis , pearson product moment correlation coefficient , white matter , nuclear magnetic resonance , magnetic resonance imaging , pathology , mathematics , radiology , physics , statistics , artificial intelligence , geometry , computer science , image (mathematics)
and correlations with clinical scores. Methods: BMS CN156-013 and CN156-018 ADwere conducted in two study groups (n1⁄4 209 mild-to-moderate AD subjects with MMSE 16-26, and 263 PDAD subjects with MMSE 24-30. PDAD subjects had objective memory loss (WMS-LM II or FCSRT), CDR-global score of 0.5 and did not meet DSM IV criteria for AD dementia. Furthermore, PDAD subjects had either CSF amyloid-beta 42 levels<200 pg/mL or total tau/amyloid-beta 42 ratio 0.39. Volumetric measures were not used as a study inclusion criterion. Hippocampal volume (HCV), brain parenchyma volume (BPV), lateral ventricles volume (LVV) and white-matter lesions volume (WMLV) were calculated from high-resolution T1 and 2D FLAIR images. Population comparison was performed using a two-tailed t-test normalized by intracranial cavity volume (ICV). The partial correlations, controlling age and ICV, were also tested between clinical scores and volumetric measurements. Results: Clinical scores (total MMSE,ADAS-cog, CDR-sb, andADCS-ADL)were all significantly different between the two study populations (P<0.0001). In PDAD subjects, normalized BPVs were significantly higher while normalized LVVandWMLV were lower. There was no significant difference in HCV between study populations. Significant correlations (r<0.3) were found between all MRI volumetric measures and all clinical scores in an analysis of the combined population. In the PDAD population, BPVwas found to be significantly correlatedwith CDR (r1⁄4 -0.44) andADCS-ADL (0.32), and HCV significantly correlatedwithADAS-cog (0.38).Conclusions:The randomized study populations of mild-to-moderate AD and PDAD were significantly different in their clinical and whole-brain MRI volumetric measures, but not in their hippocampal volumes. In the analysis of the combined population, the significant correlations betweenMRI volumes and clinical measures suggested that mild-to-moderate AD and PDAD represent a spectrum of the same disease. Further investigation regarding the utility of MRI as an alternative inclusion criterion to identify PDAD is needed.