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P4‐034: Alzheimer's disease human brain beta‐amyloid‐containing extracts inhibit hippocampal long‐term potentiation in rats in vivo : Relationship between soluble and insoluble preparations
Author(s) -
Klyubin Igor,
Mably Alexandra,
Minogue Aedín,
Hu NengWei,
Farrell Michael,
Walsh Dominic,
Rowan Michael
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1735
Subject(s) - long term potentiation , hippocampus , hippocampal formation , in vivo , stimulation , pharmacology , amyloid beta , chemistry , neuroscience , medicine , psychology , biology , disease , receptor , microbiology and biotechnology
age-matched control mice. Results: We found an age-dependent decrease in calbindin levels in ZnT3-/mouse hippocampus compared to agematched control mice. There was no difference at three months of age, a 12% decrease at six months of age, an 18% decrease at twelve months of age, and a 16% decrease at 15 months of age. Analysis of neuropeptide Y levels indicates an age-dependent increase in ZnT3-/mouse hippocampus compared to age-matched control mice. Therewas no difference at three and six months of age, a 16% increase at twelve months of age and a 43% increase at 15months of age.Conclusions:The finding of alterations in protein levels consistent with seizure activity in ZnT3-/mice indicates that sequestration of zinc may result in reduced excitatory modulation by zinc leading to hyperexcitability and increased seizure activity. This provides new insight into the mechanisms responsible for the seizure activity common in AD patients and potential targets for therapeutic interventions to ameliorate AD-related seizures.