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O4‐08‐05: 20‐year alcohol consumption patterns and cognitive impairment in older women
Author(s) -
Hoang Tina,
Barnes Deborah,
Byers Amy,
Yaffe Kristine
Publication year - 2012
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2012.05.1681
Subject(s) - medicine , cognitive impairment , dementia , cognition , alcohol consumption , prospective cohort study , cohort study , cohort , gerontology , demography , alcohol , psychiatry , disease , biochemistry , chemistry , sociology
in a prospective population-based study of 80-years or older residents in Varese province, Italy (Monzino 80-plus Study). Methods: Information on coffee drinking (number of cups per day) was obtained with a standardized questionnaire from the subject and/or a primary informant, mostly a family member. Diagnosis of dementia fulfilled DSM-IV criteria. Covariates entered in the fully adjusted logistic and Cox regression models: age, sex, education, current smoking, alcohol consumption, physical activity, BMI, depression, diabetes, hypertension, heart failure, atrial fibrillation, myocardial infarction, ictus, COPD, tea consumption. Former consumers were excluded from cross-sectional (n 1⁄4 78) and longitudinal (n 1⁄4 21) analyses. Results: The initial population consisted of 2,198 individuals (mean age: 90.2 years; women: 72.7%). Although at first visit prevalence of coffee consumption was lower among individuals affected by dementia (61.7%) compared to non-demented elderly (78.3%; p<0.0001), this difference was no longer significant after adjustment for potential confounders (fully adjusted P 1⁄4 0.5993). Consumers, on average, drank 1.460.8 cups daily. Prevalence of coffee consumption decreased with disease severity: 73.9% in mildly, 71.4% in moderately, 40.5% in severely affected individuals (p<0.0001). Non-demented individuals at first visit with at least one follow-up available were 1,101. In the following 5.5 years, coffee consumers had a lower occurrence of dementia (29.1%) than neverconsumers (41.4%; fully adjusted HR: 0.68, 95% CI: 0.52-0.90, P 1⁄4 0.0080). No significant difference was found between individuals drinking one cup and those drinking two or more cups per day (fully adjusted P 1⁄4 0.9910), while both groups showed a decreased risk of dementia compared to never-drinkers (respectively, fully adjusted HR: 0.68, 95% CI: 0.51/ 0.48-0.92/0.96, P 1⁄4 0.0128/0.0285). Conclusions: Long-term coffee consumption was associated with a 30% decreased risk of developing dementia in the oldest-old. Decreasing prevalence of coffee drinking with dementia severity could be the result of changing dietary habits along the disease course.